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Human challenge trials have never been more popular
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This week's magazine
On the cover
Table of contents
Leaders
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Physics
We may need a fourth law of thermodynamics for living systems
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Environment
Have we found a greener way to do deep-sea mining?
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Humans
Easily taxed grains were crucial to the birth of the first states
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Mind
Your brain undergoes four dramatic periods of change from age 0 to 90
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Physics
Physicists have worked out a universal law for how objects shatter
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Physics
We might have just seen the first hints of dark matter
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Humans
Ancient human foot bones shed light on how two species coexisted
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Humans
Easter Island statues may have been built by small independent groups
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Health
Monthly injection could replace daily steroid pills for severe asthma
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Life
Pandas use tools to scratch thanks to a strange evolutionary quirk
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Life
Origin story of domestic cats rewritten by genetic analysis
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Life
Deadly fungus makes sick frogs jump far, possibly to find mates
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Space
Supermassive dark matter stars may be lurking in the early universe
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Chemistry
Plastic can be programmed to have a lifespan of days, months or years
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Health
Upheavals to the oral microbiome in pregnancy may be behind tooth loss
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Humans
Warming and droughts led to collapse of the Indus Valley Civilisation
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Environment
Africa’s forests are now emitting more CO2 than they absorb
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Technology
Why Google’s custom AI chips are shaking up the tech industry
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Life
Cats can overcome fear of water to benefit from aquatic therapy
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Life
IUCN report finds more African forest elephants than we thought
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