馃挰 Artificial intelligence and big data are flooding discovery pipelines with high-potential drug candidates, but this rapid innovation has triggered a crisis. Simply put, our capability to design miracle molecules is vastly outstripping our technology to mass-manufacture them safely for the global public. Moving drug making from the scale of lab flasks to commercial bioreactors introduces non-linear biological and engineering shifts that can undermine tasks like purification.

鈿n this 快猫短视频 CoLab podcast, experts from global life sciences leader Cytiva explain the hidden, high-stakes science of purification that is required to close the gap between drug discovery and the pharmacy shelf.

Our guests are:

Henrik Ihre, Distinguished Fellow, Cytiva

Paul Belcher, Business Leader, Cytiva

馃帶 Stay tuned to learn about:

鉃� The process of taking a drug from theoretical to the shop shelf

鉃� How the drug purification works

鉃� The human cost when purification goes wrong

鉃� The challenges of keeping pace as AI supercharges drug discovery

Chapters:

(00:00) Intro – How drugs go from discovery to reality

(03:49) The purification process

(10:05) Why small scale success doesn’t mean industrial scale success

(13:00) The challenge of the expanding drug pipeline

(21:39) Understanding the molecules that are being purified

(23:20) What is a chromatography resin?

(25:24) Why purification gets more difficult later in the process

(27:15) The human impact when purification goes wrong

(32:59) The future of AI drug discovery

(37:52) Is AI helping with purification?

(40:32) How it feels to be advancing drug discovery

About the sponsor:

Cytiva:

About the podcast:

快猫短视频 CoLab explores the boundaries of innovation and the intersection of business, science and technology. Hosted by Justin Mullins.

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They are joined by neuroscientist听Michael Leon, who explains what happens when we lose our sense of smell, and staggeringly that simply enriching your life with听 pleasant scents could help protect you from diseases like Alzheimer鈥檚.

Produced by Emily Bird

We want to hear your thoughts, leave a comment or send in your ideas for future episodes to听鈦犫仩鈦犫仩鈦�changeyourmind@newscientist.com鈦犫仩鈦�

Find out more about your senses at 快猫短视频:

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Learn more about our sponsor Alzheimer鈥檚 Society:
鈦犫仩鈦犫仩鈦犫仩鈦�/补濒锄丑别颈尘别谤蝉-蝉辞肠颈别迟测/鈦犫仩鈦犫仩鈦犫仩

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快猫短视频s have created a synthetic cell with just 36 genes that can copy DNA and replicate. In an attempt to create a 鈥渕inimal cell鈥�, a team led by professor Kate Adamala have built 鈥淪pudCell鈥� from the ground up, using non-living components.

But is it alive – and is it dangerous? Despite being able to carry out some of the tasks of a normal cell, it鈥檚 not clear that it鈥檚 capable of evolution – yet. But it is a major breakthrough in the field and could pave the way for the creation of artificial life in the future.

Researchers have made their work open source so the next breakthrough can be fasttracked – and hope it will help provide a solution to the climate crisis by replacing the need for petrochemicals.

To discuss the news – and its implications for the origin of life – Rowan Hooper and Penny Sarchet are joined by 快猫短视频 reporter Michael Le Page.

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Advances in sports science, data analysis and AI are having a huge impact on the way football is played. With England rated highly in this year鈥檚 World Cup, and teams such as Paraguay causing upsets – how will science help give teams an edge?

In the past there was very little data available to help assess player performance – and diet and training were much more rudimentary. But now we can analyse information in an incredibly sophisticated way, which is changing what players can achieve on the pitch.

In this special World Cup episode recorded at the Royal Society in London, we explore the emerging role of data and AI in football, the neuroscience of penalty shootouts, the impact of extreme heat on player performance, differences between the men鈥檚 and women鈥檚 game – and much more.

Rowan Hooper is joined by a panel of expert guests, including:

Dr Charlotte Cowie, Chief Medical Officer of the British Olympic Association

Dr Ian Graham, Founder of sports advisory business Ludonautics

Holly Bridge, Professor of Neuroscience at University of Oxford

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Image credit: Ank Kumar, CC BY-SA 4.0 via Wikimedia Commons听

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In this episode of Change Your Mind from 快猫短视频, Helen and Cat explore the surprising science of solitude, including how it differs from loneliness and why time alone can sometimes even improve our connections with other people. They鈥檙e joined by听Netta Weinstein, a psychologist at the University of Reading, UK, and co-author of听Solitude: The Power and Science of Being Alone, to discuss how much time alone is actually good for your brain. And how do you make the most of your alone time to restore your mood, creativity and patience?听