A large聽genetic study of people with acne could pave the way for new treatments. The study looked at the DNA of聽27,000聽people, including聽over 5000 with severe acne, and identified genetic differences that were more common in people with the condition.
It found that many of these genetic variants influenced the formation of hair follicles, making it a significant but previously unknown risk factor in developing acne.
There have been few advances in acne treatment for decades, says聽Jonathan Barker at the National Institute for Health Research, UK, who led the study. He hopes聽that using the new genetic information could lead to much more effective drugs and treatment for the condition.
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Acne is a common skin condition affecting 80 per cent of people aged 11-30, causing spots, oily skin and sometimes skin that is hot or painful to touch. In severe cases it can cause significant discomfort and distress and can lead to permanent scarring.
The most effective current treatment for acne is isotretinoin, but the team said this has significant side effects including muscle aches and dry skin as well as birth defects if taken by pregnant women.
Nature Communications
