
Boy or girl? Pregnant women can now find out the sex of their fetus with a simple finger-prick test.
Until recently, expectant mothers usually had to wait until a mid-pregnancy ultrasound to find out their future child’s sex.
But in the last few years, increasing numbers of people have been finding out from a first-trimester blood test – called the – that also detects Down’s Syndrome.
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The test works by analysing fragments of the fetus’s DNA that have leaked into the mother’s bloodstream. It involves collecting about 20 millilitres of blood from the mother’s arm with a needle and syringe.
Ƿ, at Sabin Laboratory, a medical diagnostics company in Brazil, has made the test even simpler. His team has shown that a single drop of blood from a pregnant woman’s fingertip is enough to determine her fetus’s sex.
In a study of 100 pregnant women, they found that fingertip blood could be used to predict fetal sex with 100 per cent accuracy from 8 weeks’ gestation onwards.
The procedure was simple: they wiped each woman’s fingertip with dilute bleach to get rid of any foreign DNA that might contaminate the sample. A single drop of blood was collected by pricking her finger.
Each blood sample was then scanned for Y chromosome DNA. Only males carry the Y chromosome, so if it turned up in the mother’s blood, it must have come from her male fetus. If no Y chromosome was detected, the fetus had to be female.
Y do it?
The advantage of the finger-prick test is that it is faster, more convenient, and better for women who are scared of needles, says Barra. He believes women will have access to the test “very soon”.
However, because it detects the fetus’s sex early in pregnancy, there is a risk it could lead to more sex-selective abortions, says at Royal North Shore Hospital in Sydney, Australia.
Sex-selective abortions are already known to happen in places like IndiaԻChina, usually just after the mid-pregnancy ultrasound. Being able to test the fetus’s sex earlier could make this practice more common.
Generally, there’s no medical reason for checking the sex of a fetus in the womb – it’s mainly just for the parents’ interest, says McLennan. The exception is if a baby is at risk of having a serious genetic condition that depends on its sex, he says. For example, sons, but not daughters, can inherit Duchenne muscular dystrophy from their mother if she is a carrier.
Barra is now studying whether the finger-prick test can also be used to diagnose genetic conditions like Down’s syndrome in first trimester fetuses.
Prenatal Diagnosis