
Last week, crippling pelvic pain landed me in hospital. A doctor prescribed a course of antibiotics lasting just three days. I couldn’t help worrying that it wasn’t long enough. What if my infection hadn’t cleared by then? What if some of the harmful bacteria survived the treatment, and my body incubated the deadly, drug-resistant superbugs we have all been warned about?
Really, I had nothing to worry about: growing evidence suggests that short courses of antibiotics can be just as effective at killing bacteria as longer ones. And they don’t increase the risk of antibiotic resistance, at least for the common infections that most people receive antibiotics for.
In fact, it is the longer courses that cause problems. In 2010, an analysis of 24 studies, which included thousands of patients with respiratory and urinary tract infections, found that people on longer courses of antibiotics were .
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That’s because most of the drug-resistant infections we are worried about stem from “friendly” bacteria that normally live in peace on and in our bodies. When we take antibiotics, we wipe out friendly gut bacteria along with the harmful ones. This disruption to the ecosystem can allow once-friendly bacteria from elsewhere in the body to colonise, where they can turn hostile and cause problems. Because these species weren’t killed by the antibiotic, any infections they cause are resistant to it. And this is more likely to happen with a longer course of treatment.
So why do many prescriptions tend to last for one or two weeks? When at Brighton and Sussex Medical School in the UK tried to find the origin of antibiotic prescription lengths, he struggled. “It appeared that people working in the 1950s arrived at these, probably because they were worried that people would otherwise skimp on treatment, or because they were afraid of resistance,” he says.
“No medical basis”
Antibiotics are often prescribed in multiples of five or seven days. This is probably because these numbers correspond to the number of fingers on a hand and the number of days in a week, but there’s no medical basis, says Llewelyn, who co-authored a letter on the subject in the BMJ today. In fact, it might be a better idea to stop taking antibiotics once you feel better, and symptoms are resolved, he says.
The notion of cutting down overly long antibiotic courses isn’t new. The UK health agency Public Health England and the US Centers for Disease Control have both changed their guidance on antibiotic prescribing in recent years, based on an understanding of the evidence. Both organisations have ditched their “complete the course” messages for ones that focus on following a doctor’s advice.
But the World Health Organization continues to promote the idea that completing a course of antibiotics is a . It’s an outdated position, and it’s time the WHO modified its stance.
In the meantime, people who are diagnosed with bacterial infections can discuss the course of treatment with their doctors – who also might not be up to date with the latest evidence. Three days of antibiotics worked in my case, and I’m pleased my doctor didn’t ladle me with extra medication when I didn’t need it.
BMJ
Read more: Antibiotics apocalypse: Tales from fighters on the front line; Antibiotic resistance will hit a terrible tipping point in 2017