快猫短视频

A MUTANT gene that increases the risk of a common type of testicular cancer
fifty-fold has been located by an international team of geneticists. Testicular
germ-cell cancer is the commonest cancer among young males in Western
Europe.

Men inherit TGCT1, the gene linked to this form of cancer, from
their mothers. Its discovery was announced in London this week by three of
Britain鈥檚 leading cancer research charities.

Looking for the gene was complicated, because TGCT1 is not the only
gene involved in testicular cancer. 快猫短视频s isolated the DNA of cancer
patients from 134 families and looked for easily recognisable genetic markers,
or tags, in the families鈥� DNA.

鈥淚f one of these tags is always inherited with the disease, then we know that
a gene for the disease must be close to the tag,鈥� says Liz Rapley, a geneticist
at the Institute of Cancer Research in Sutton, Surrey.

Researchers have narrowed down the whereabouts of TGCT1 to a small
region of the X chromosome, which contains at least 300 genes. They hope to
pinpoint the gene itself in the next 2 to 5 years so that men with the gene, who
have a high risk of developing testicular cancer, can be screened for the
disease. 鈥淚f it is detected early, we can cure testicular cancer in 95 per cent
of cases,鈥� says Rapley.