快猫短视频

Rubbing takes the pain away

CONNING your kids that their mumps jab won鈥檛 hurt could soon be unnecessary.
Researchers in the US say that a technique that allows vaccines to be absorbed
through the skin could lead to needleless immunisations within ten years.

Gregory Glenn and his colleagues at the Walter Reed Army Institute of
Research in Washington DC report in this week鈥檚 Nature (vol 391, p 851)
that adding cholera toxin to diphtheria and tetanus vaccines enables rats to
absorb the vaccines through the skin.

After applying the mixtures to the skin of rats, the researchers detected
strong antibody responses to the diphtheria and tetanus pathogens. Their
subsequent research suggests that this type of vaccination might work against a
wide range of diseases.

快猫短视频s already knew cholera toxin acts as an 鈥渁djuvant鈥, a compound used
to boost the immune response to vaccines. Glenn says the toxin activates special
cells in the skin, called antigen presenting cells, which are vital for the
production of antibodies. 鈥淲e hope this will open up a whole new method of
vaccine administration,鈥 says Glenn. 鈥淭his could be extremely important in the
developing world, where trained staff and clean needles aren鈥檛 always at hand.
As a paediatrician, that鈥檚 the thing I find most exciting.鈥

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